2017. Lebrun-Frenay C et al. – New insights into the burden and costs of multiple sclerosis in Europe: Results for France


Lebrun-Frenay C, Kobelt G, Berg J, Capsa D, Gannedahl M; European Multiple Sclerosis Platform. New insights into the burden and costs of multiple sclerosis in Europe: Results for France. Mult Scler. 2017 Aug;23(2_suppl):65-77.


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INTRODUCTION: To estimate the value of interventions in multiple sclerosis (MS) – where lifetime costs and outcomes cannot be observed – outcome data have to be combined with costs. This requires that cost data be regularly updated.

OBJECTIVES AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of severity, in the societal perspective, in EUR 2015.

RESULTS: A total of 491 patients (mean age 47 years) participated; 82% were below retirement age, and of these 56% were employed. Employment was related to disease severity, and MS affected productivity at work for 90% of patients. Overall, 95% and 67% of patients experienced fatigue and cognition as a problem, respectively. The mean utility and annual costs were 0.735 and €22,600 at Expanded Disability Status Scale (EDSS) 0-3, 0.500 and €38,100 at EDSS 4-6.5, and 0.337 and €48,100 at EDSS 7-9, respectively. The average cost of a relapse was estimated at €2300.

CONCLUSION: This study provides current data on MS in France that are important for developments of health policies and to estimate the value of current and future treatments.